The Early Intervention Mission Study

Improving our understanding of the progression of psychosis over time can provide valuable insights into the early risk markers of more detrimental long-term outcomes, as well as the potential early intervention avenues to change these outcomes.

This can support more personalised approaches to assessment, treatment, and allocation of resources to individuals at greatest risk, helping to reduce or even prevent poor psychiatric, social, functional and physical outcomes in this population. Several strands of evidence on personalised approaches for early psychosis hold promise. One is use of blood biomarkers, to identify which treatments a patient is likely to respond to. Another is using routinely collected information (sex, age, medication, routine blood tests) to inform predictive treatment. These have been applied in small samples of patients, but a larger scale study to improve the accuracy of these tools is needed.

The study has 3 main aims:

• Advance precision medicine through research into risk stratification, tailored prevention, and early interventions.
• Improve our understanding of the longitudinal course and treatment of early psychosis.
• Create a Research Register for Targeted Recall for Future Observational and Interventional Research studies.